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CONTENTS 2004
We have organized the Content Archive by year. Each year’s list contains all the articles published in that year, organized by category (i.e., Articles, Buzz, Data Mining, Focal Point, Mayday, Recapping The Week, School Zone, Signals vs. Noise, Turn Signals and Trivia). To search by year, click the appropriate link on the left.

Articles Buzz Focal Point Data Mining Mayday
Recapping The Week School Zone Signals vs Noise Turn Signal Trivia

Articles

12/22/2004Winning The Drug-Approval Game: 2004
The odds of winning coveted FDA approval have always been outrageously low, yet many firms possess the skill and luck that allow them to triumph in the end. And 2004 was no exception: Biotechs brought 23 new drugs to market, many of which are first-in-kind therapies.


11/23/2004Striking Down Parkinson’s
New approaches for treating the debilitating symptoms of Parkinson’s disease – some of them aimed at slowing disease progression or even regenerating damaged nerves – may provide a major victory for patients and doctors alike.


10/20/2004Biomarkers: The Pendulum Finally Swings
Biomarkers are already used routinely in R&D programs, but few firms have been willing to spend the money to incorporate them into clinical studies. That is, until the Vioxx disaster, which showed just how expensive it can be to not do so.


9/14/2004The Ties That (Don’t) Bind
Innovation, creativity, a collegial environment – these are all keys to Roche’s laissez faire approach to its biotech partnerships. Respecting autonomy and remaining flexible worked with Genentech, and it’s still working today.


8/09/2004New Kids On The Block
Members of the IPO Class of 2003-2004 burst upon the public scene with finely honed skills that set them aside from the previous generation. They’ve got drugs in the clinic already --- among them new anti-infectives that are set to soar.


7/09/2004BioShield And Beyond
Biotech firms have responded rapidly to the government’s call for new vaccines and drugs for biodefense, and Project BioShield guarantees them a buyer in the end. But where do they find the money for R&D and clinical trials?


6/04/2004The Tech Transfer Pie
Nearly all academic institutions now out-license their IP for commercial development, but some are savvier than others when it comes to maximizing the rewards they reap from their inventions.


5/07/2004The Eyes Have It
Until recently, few firms recognized the huge unmet medical need for new therapies to treat AMD and diabetic retinopathy – dreadful diseases that blind millions of people. But perception has changed radically – and dozens of drugs are now in the clinic.


4/02/2004The Licensing-Go-Round
In-licensing, out-licensing, returned rights, terminated deals, re-partnering -- they’re all part of the dizzying business of drug development. But some product candidates go around so often that it’s hard to remember where they started.


3/05/2004Armed Antibodies
It’s become quite clear that most monoclonals are not very good at killing cancer cells on their own. That’s why there’s been a resurgence of interest in antibodies that deliver a lethal payload — be it a drug, a toxin or a radionuclide.


2/06/2004The New Product Parade
Early on, biotech firms marched to a different drummer than big pharmas, focusing on protein therapies rather than small molecule drugs. Today, however, they’re in step, as the types of new biotech medicines approved in 2003 clearly show.


1/09/2004Financing Finally Flows
The biotech industry’s pent-up demand for life-sustaining cash was finally satisfied in 2003 with an eruption of $16.7 billion in new financing -- making it the second biggest annual haul in the sector’s history.

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Buzz

11/10/2004Wake Up Call For Vaccines

10/06/2004Ahead Of The Curve

8/27/20042004 Product Sales Will Easily Clear The $50B Mark

7/02/2004A Hard Act To Follow

6/02/2004BIO’s Feldbaum: It’s Been A Wild Ride

4/22/2004Full Steam Ahead

3/10/2004Robust Sales Drive Sector

2/09/2004FDA’s New Initiatives Taking Off

1/06/2004IPO Monitor
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Data Mining

9/24/2004Second Quarter 2004 Alliance Scorecard – Earned Revenues Top $1.4B YTD

7/30/2004First Quarter 2004 Alliance Scorecard – Chemistry, Cancer Coming On Strong
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Focal Point

12/16/2004Giant Steps In Genetics

10/27/2004Late-Stage Deals Have Lots of Appeal

9/16/2004Agbiotech Roulette

7/15/2004U.K., U.S. Cooperate, Compete On Anthrax Vaccine

6/17/2004A Peek Into Biotech’s Future

5/04/2004The Next Tidal Wave?

3/19/2004Sanofi: Leader Of The Pack?

2/12/2004Partners Bid Up Mid-Stage Deals

1/21/2004IPO Step-Ups & Valuations: Then & Now
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School Zone

12/03/2004Universities Reap Bayh-Dole’s Benefits

2/27/2004Alliances: La Crème de la Crème
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Signals vs Noise

10/08/2004Financial Snapshot For September 2004: In Need Of A Boost

7/07/2004Financial Snapshot For June 2004: Lackluster Performance

4/14/2004Financial Snapshot For March 2004: Looking Good

1/16/2004Financial Snapshot For December 2003: Bulls Charge Ahead
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Turn Signals

10/29/2004BECIF: New Faces, Old Favorites

10/01/2004Foundations Spark Research on Rare Diseases

8/17/2004Turn The Page

6/28/2004Dramatic Turns In Drug Development

5/17/2004How To Land A Big Fish

3/24/2004Allicense 2004: Come Meet The Winner

2/23/2004Hunting For Crown Jewels

1/26/2004JPMorgan Conference 2004, Orange Bags And All
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Trivia

12/29/2004Cherry Pie

12/22/2004Epigenetics

12/15/2004Amyris

12/08/2004Sunlight

12/01/2004Typhoid fever

11/24/2004Spanish Gene

11/17/2004Poppy

11/10/2004Origins

11/03/2004Incyte IPO

10/27/2004Repetitive DNA

10/20/2004Conan

10/13/2004Muscle

10/06/2004Intarcia

9/29/2004Essential

9/22/2004Pets

9/15/2004Pathema

9/08/2004Cotton

9/01/2004Sirtuin

8/25/2004CAG

8/18/2004Teeth

8/11/2004Worm

8/04/2004Amish Babies

7/28/2004Well, Well

7/21/2004Cellumen

7/14/2004Pre-GNE

7/07/2004Greek To Me

6/30/2004Asses

6/23/2004Fat Mice

6/16/2004Knighthood

6/09/2004First Convention

6/02/2004Doggies

5/26/2004Targacept

5/19/2004Receptor

5/12/2004Aspreva

5/05/2004Heavy Chain

4/28/2004HDL

4/21/2004Splits

4/14/2004Rats

4/07/2004Chromosomes

3/31/2004Jazz

3/24/2004Cell Genesys

3/17/2004Inhibitor

3/10/2004Sargasso

3/03/2004Xoma

2/25/2004Double Helix

2/18/2004Big Deal
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Copyright © 2012. Signals (signalsmag.com) is an online magazine of analysis for biotechnology executives. To contact the Signals editorial department, send e-mail to signals_edit@deloitte.com. Signals is published by: Recap, 2033 N Main Street, Suite 1050 , Walnut Creek, California 94596-3722, Phone: (925) 952-3870